Open Notebook Science Using Blogs and Wikis

The first half is a summary of how the Bradley group at Drexel University is doing Open Notebook Science with the UsefulChem project to synthesize and test novel anti-malarial compounds. Graduate student Dave Strumfels' code to compute kinetics from JCAMP NMR reaction profiles is then highlighted. Finally screenshots are shown of a building on Nature Island in Second Life where Beth Ritter-Guth and Eloise Pasteur have helped to set up a poster room with NMR spectra, molecules and an organic chemistry quiz that can be activated by clicking on an obelisk. 
&#xa

The CombiUgi Project and Closing the Open Science Loop

This presentation combines 2 blog posts explaining the CombiUgi project and the predicted anti-tumor activity of a virtual library of 68,000 compounds

The Role of Metadiscourse in Negotiating Trust in the Communication of Science by Blog

119-142Advocates for open systems in science make claims for their efficient collaboration and transparent communication. Although these characteristics are consistent with the traditional norms of science, the implementation of open systems has had mixed effects, particularly on the role of trust. This case study of the published correspondence in research journals suggests that when communication moves from traditional print systems to open on-line systems, two levels of trust arise, one at the discourse level and another at the metadiscourse level. The coincidence and conflation of discourse in these two registers both ameliorate and trouble trust in the communication of science. Taken together, these methodological issues raise doubts about the validity of Wolfe-Simon et al.’s assertion … (Redfield, 2011). I don’t know whether the authors are just bad scientists or whether they’re unscrupulously pushing NASA’s ‘There’s life in outer space!’ agenda (Redfield, 2010)

Open Notebook Science Challenge: Solubilities of Organic Compounds in Organic Solvents

This book contains the results of the Open Notebook Science Solubility Challenge. All experimental measurements are provided with a link to either the laboratory notebook page where the experiment was carried out or to a literature reference. The Challenge was sponsored by Submeta, Nature and Sigma-Aldrich

Open Notebook Science Challenge: Solubilities of Organic Compounds in Organic Solvents

This book contains the results of the Open Notebook Science Solubility Challenge. All experimental measurements are provided with a link to either the laboratory notebook page where the experiment was carried out or to a literature reference. The Challenge was sponsored by Submeta, Nature and Sigma-Aldrich

170 GBit/s transmission in an erbium-doped waveguide amplifier on silicon

Signal transmission experiments were performed at 170 Gbit/s in an integrated $Al_2O_3:Er^{3+}$ waveguide amplifier to investigate its potential application in high-speed photonic integrated circuits. Net internal gain of up to 11 dB was measured for a continuous-wave 1532 nm signal under 1480 nm pumping, with a threshold pump power of 4 mW. A differential group delay of 2 ps between the TE and TM fundamental modes of the 5.7-cm-long amplifier was measured. When selecting a single polarization open eye diagrams and bit error rates equal to those of the transmission system without the amplifier were observed for a 1550 nm signal encoded with a 170 Gbit/s return-to-zero pseudo-random $2^{7}-1$ bit sequence

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

The optimization of a Ugi reaction involving the mixing of furfurylamine, benzaldehyde, boc-glycine and t-butylisocyanide is described. Triplicate runs of 48 parallel experiments are reported, varying concentration, solvent and the excess of some of the reagents. The isolation of the product was achieved by a simple filtration and wash procedure. The highest yield obtained was 66% from 0.4 M methanol with 1.2 eq. of imine. This is significantly above the 49% yield obtained from the initial reaction under equimolar concentration at 0.4 M in methanol. Methanol solutions with reagent concentrations of 0.4M or 0.2M gave superior yields while all solvent systems at 0.07M performed poorly. At 0.2M, methanol and ethanol/methanol (60/40) mixtures were statistically equally good while THF/methanol (60/40) was poor and acetonitrile/methanol (60/40) was intermediate. Good reproducibility of the precipitate yields was obtained in these replicate experiments, allowing for subtle interaction effects to be positively identified

Chemistry in Second Life

This review will focus on the current level on chemistry research, education, and visualization possible within the multi-user virtual environment of Second Life. We discuss how Second Life has been used as a platform for the interactive and collaborative visualization of data from molecules and proteins to spectra and experimental data. We then review how these visualizations can be scripted for immersive educational activities and real-life collaborative research. We also discuss the benefits of the social networking affordances of Second Life for both chemists and chemistry students